Author:
I.N. KURDYUMOV¹, T.S. GAN^,SHINA¹, D.V. MASLENNIKOV¹, E.V. KURZA¹, A.A. GORBUNOV^1,2, A.I. TURILOVA¹ and R.S. MIRZOYAN¹

¹ V.V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, ul. Baltiiskaya 8, Moscow. 125315 Russia

² I.M. Sechenov First Moscow State Medical University (Sechenov University), ul. Trubetskaya 8, Moscow, 119881 Russia

Summary:
Comparative study of the effect of mexidol and hemisuccinate 2-ethyl-6-methyl-3-hydroxypyridine on the cerebral circulation of rats under conditions of hemorrhagic and ischemic brain lesions revealed significant differences in their cerebrovascular effects. Mexidol at a dose of 200 mg/kg i.v. better improves the local cerebral blood flow in modeling ischemia as compared to hemorrhagic brain damage. Hemisuccinate 2-ethyl-6-methyl-3-hydroxypyridine at a dose of 50 mg/kg better enhances the local blood supply to the cerebral cortex under conditions of hemorrhagic brain damage as compared to ischemic damage, since its cerebrovascular effect during cerebral ischemia occurs in a dose of 100 mg/kg. The mechanism of cerebrovascular anti-ischemic effect of 2-ethyl-6-methyl-3-hydroxypyridine hemisuccinate is mediated by GABAa receptors of the brain vessels, since bicuculline eliminates this effect.

Keywords: mexidol; hemisuccinate 2-ethyl-6-methyl-3-hydroxypyridine; bicuculline; cerebral circulation; hemorrhagic stroke model; global transient ischemia.