Use and outcomes of antioxidant therapy in ophthalmic practice


1Hospital for War Veterans No. 2, Moscow, Russia;

2Pirogov Russian National Research Medical University, Moscow, Russia;

3N.P. Bochkov Research Centre for Medical Genetics, Moscow, Russia

Advances in medical diagnostic technologies, particularly in ophthalmology, help researchers understand histological characteristics of the human eye and study vision at the cellular level. In addition to its role in the ocular function associated with the control of movements, senses and protective responses, the nervous system plays a key role in regulation of the visual process. Neurodegenerative disorders hold a special place among systemic diseases. Presently, the development of such pathologies are associated with neuroinflammation, which has been proven to also contribute to the glaucomatous process. For this reason, achieving target intraocular pressure does not always guarantee stabilization of the degenerative process. In this context, neuroprotective agents are recommended for glaucoma management to all patients taking into consideration pathogenetic characteristics of the disease. Based on its antioxidative and neuroprotective effects, ethylmethylhydroxypyridine succinate (Mexidol) is commonly used in ophthalmic practice, specifically in the treatment of patients with glaucomatous optic neuropathy and retinal diseases. The results of studies demonstrate that Mexidol is effective in slowing down neurodegeneration and stabilizing visual functions in patients with primary open-angle glaucoma due to its antihypoxic, antioxidant and membrane-stabilizing properties, as well as its positive impact on the neuromediator balance and ocular blood flow.
Keywords: ophthalmology, eye, neuroinflammation, glaucoma, glaucomatous optic neuropathy, neuroprotective therapy, ethylmethylhydroxypyridine succinate, Mexidol, Mexidol FORTE 250.