Efficacy of Mexidol in patients with type 2 diabetes mellitus with neurological complications


Pavlov First Saint Petersburg State Medical University, St. Petersburg, Russia

Objective. Complications of Diabetes mellitus (DM), depends on the severity of hypoxic tissue damage. Amelioration of hypoxic injury may improve current therapy approaches and enhance the quality of life in patient’s cohort suffered from DM. Material and methods. 30 pts which DM were enrolled into the study. Mexidol forte, was given IV 500 mg/day for 14 days, follow up with oral administration 250 TID. Clinical impression, neuropsychological scales and biochemical blood tests were recorded. Results. Mexidol administration improved cognitive functions, decreased the level of asthenia, depressia, improved sleep disturbances, and normalized biochemical landscape. Conclusions. Mexidol administration for the period 75 days may serve as important therapeutic supplementation and considered as adjunctive therapy in the treatment of patients with DM. Keywords: Diabetes mellitus, hypoxia, oxidative stress, antioxidants, neurotransmitters, antihypoxive medications, Mexidol.