Clinico-psychological profile and life quality of patients with post-COVID syndrome

Tver State Medical University, Tver, Russia

Objective. To study clinico-psychological profile and life quality of patients with post-COVID syndrome. Material and methods. We examined 162 patients aged 24-60 years with confirmed SARS-CoV‑2 infection which having symptoms that served as the basis for the diagnosis of post-COVID syndrome. Patients underwent general neurological and somatic examination with allocation of the corresponding neurological syndromes. The intensity and quality of pain were assessed using the McGill Pain questionnaire. The level of psychosocial stress was determined by the Holmes-Ray questionnaire, the identification and severity of asthenia — by the MFI-20 asthenia scale. The level of reactive and personal anxiety was studied according to the Spielberger—Khanin questionnaire, depression — according to the Beck scale. The assessment of life quality was carried out using the Russian version of SF-36 questionnaire. To correct the identified disorders, Mexidol was used according to the scheme: 500 mg once daily intravenously for 14 days, followed by Mexidol FORTE 250 750 mg per day orally (250 mg 3 times a day) for 2 months. Results. The course of treatment with Mexidol in patients with post-COVID syndrome led to decrease in the severity of subjective and objective symptoms, asthenic, anxiety and depressive disorders, and improved the life quality of patients. Conclusion. The high efficacy and safety of sequential therapy with Mexidol (injections followed by tablets of Mexidol FORTE 250) has been shown. Keywords: post-COVID syndrome, SARS-CoV‑2 infection, emotional disorders, anxiety, depression, life quality, Mexidol.