Role of antioxidants in treatment and prevention of patients with high risk of cardiovascular complications

Author:
L.A. SHCHEPANKEVICH, M.M. TANASHYAN, YU.A. NIKOLAEV, V.YA. POLYAKOV, M.A. PERVUNINSKAYA, K.V. ANTONOVA
Research Institute of Experimental and Clinical Medicine, Novosibirsk, Russia; Neurology Research Center, Mosсow, Russia

Summary: 
Aim — to estimate effect of Mexidol on blood lipids in patients with high cardiovascular risk and diabetes mellitus type 2 (DM2). Material and methods. Two groups of patients with DM2 as the main risk factor of vascular complications were prospectively followed-up within 3 months. Achievement of target blood lipid was compared in standard therapy with statins (group 1) and addition of Mexidol to basic therapy (group 2). Enzymatic colorimetric method was used to determine blood lipids level (Boehringer Mannheim, Germany). Results. There was a positive effect of Mexidol at the initial stage of statins therapy that was expressed by normalized lipids level in DM2 patients with high and very high cardiovascular risk.

Keywords: cardiovascular complications, diabetes mellitus type 2, dyslipidemia, prevention, Mexidol.