Preventive therapy with mexidol in toxic damage to the heart

Author:
M.D., ASSOCIATE PROFESSOR E.I. POLOZOVA
Ogarev Mordovia State University, Saransk, Russia

Summary:
The purpose of this study was to efficacy of mexidol in the prevention of toxic damage to the heart in acute pancreatitis. Material and methods. The paper presents the results of experimental studies conducted on 30 adult mongrel adult dogs, which simulated acute focal pancreatic necrosis. We studied the influence of mexidol in the complex therapy for changes in the qualitative and quantitative composition of the lipid tissue structures of the heart, the intensity of processes of lipid peroxidation, antioxidant capacity, phospholipase A2 activity and morphofunctional state of the heart muscle in experimental acute focal pancreatic necrosis. The results and discussion. The preventive use of antioxidant drug mexidol in complex treatment of acute focal pancreatic necrosis, which limits the development of endogenous intoxication, increased intensity of lipid peroxidation and restores antioxidant capacity, reduces leading to phospholipase activity in tissue structures of the heart, corrigiruet lipid metabolism and morphofunctional state of the heart, and, consequently, toxic damage to the heart during endotoxic.

Keywords: pancreatitis, endogenous intoxication, heart, mexidol, antioxidant system, lipid.


The efficacy of mexidol in carotid endarterectomy procedure in patients with cerebral atherosclerotic stenosis

Author:
V.I. GOLOVKIN, A.V. SVETLIKOV, A.S. SHAPOVALOV, L.O. POPOVA
North-Western State Medical University named after I.I. Mechnikov, Saint-Petersburg

Summary:
Objective - to determine the antihypoxic efficacy of mexidol in carotid endarterectomy (CE) procedure in patients with cerebral atherosclerotic stenosis using cerebral oximetry. Material and methods. Clinical/psycho/neurological monitoring was performed in 109 patients with internal carotid artery stenosis of 69±7.0% and neurological symptoms of cerebral ischemia, 2-3 degree, in pre- and postoperative periods. Cerebral oximetry was carried out perioperatively. Fifty-four patients were treated with mexidol in a dose of 1000 mg/day for 14—15 days and 55 patients did not received mexidol. Results and conclusion. The difference in initial brain oxygenation (rSO2) between the main and comparison groups was shown (60.8±5.0 and 47.29±5.5%, respectively). During operation, the degree of blood oxygenation in these groups decreased by 57% and 41%, respectively. On day 7, significant differences in the Schulte test in two groups of patients with similar neurological status were found considering efficiency of work and mental stability before and after operation. No differences were found in the comparison group. Mexidol used for antihypoxic brain protection in carotid endarterectomy of patients with cerebral atherosclerotic stenosis significantly reduces the degree of cerebral hypoxia, decreases the duration of surgery, improves neurological status of patients and performance of psychological tests in postoperative period.

Keywords: cerebral stenosis, cerebral ischemia, carotid endarterectomy, cerebral oximetry, mexidol.


To efficiency of the use of mexidol for patients by a chronic pancreatitis in the stage of intensifying

Author:
LYSENKO S.G.,
PhD of Biological Sciences, Associate Professor of department of biology of the Luhansk National university, Luhansk
KHOKHLOVA A.V.,
Master’s degree of department of Biology of the Luhansk National university, Luhansk
DEMIDENKO V.V.,
Manager by a surgical separation, Surgeon of higher category of the Luhansk municipal multi-field hospital 3, Luhansk

Summary:
Abstract. Studied the problems of treatment and modern prophylaxis for the patients of suffering a chronic pancreatitis. Influence of mexidol is analysed on the biochemical indexes of blood, glucose of blood. Proved, that mexidol applied in a complex with standard therapy, able to influence reparative processes in a pancreas. On the basis of undertaken a study it is suggested to apply mexidol authors additionally with basic therapy, for patients by a chronic pancreatitis, with the purpose of facilitation of flow of this disease and decline r risk of development of complications requiring an.

Keywords: chronic pancreatitis; mexidol; amylase; thymol test; urea; blood glucose; treatment; preventive maintenance; reparative.


Increase of relaparotomy efficacy in peritonitis manapement

Author:
A.P. VLASOV, E.K. SALAKHOV, O.YU. RUBTSOV
N.P. Ogarev Mordovia State University

Summary:
Keywords: relaparotomy, peritonitis, abdominal sanitation, enteral lavage, mexidol.