The study of the neuroprotective effect of mexidol on the cellular model of glutamate stress

Author:
O.A. GROMOVA, I.YU. TORSHIN, E.V. STELMASHUK, O.P. ALEXANDROVA, A.V. PRONIN, I.V. GOGOLEVA, L.G. HASPEKOV
Federal Research Center «Informatics and Cybernetics», RAS, Moscow, Russia; Scientific Center of Neurology, Moscow, Russia; Ivanovo State Medical Academy of the Ministry of Health of Russia, Ivanovo, Russia

Summary:
Purpose of the study. Study of neuroprotective properties of mexidol on a cellular model of glutamate stress. Material and methods. Cytological studies were carried out under the conditions of the model of glutamate stress in the culture of granular neurons of the cerebellum. Results. The addition of mexidol to the cultural medium increased the survival of neurons by 8-10% after the addition of glutamate (p<.05). The effect of mexidol was more pronounced when applied at the stage of growing the culture of neurons (5 days), when the survival of the cells in conditions of glutamate stress increased by an average of 20%. The conclusion. The results of the study confirm the direct neuroprotective effect of mexidol in the culture of neurons under the conditions of the glutamate stress.

Keywords: cellular stress, excitotoxicity, glutamate, mexidol.